Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors

Authors
Wu, XJ Tang, XP Xian, M Wang, PG
Citation
Xj. Wu et al., Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors, TETRAHEDR L, 42(23), 2001, pp. 3779-3782
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
23
Year of publication
2001
Pages
3779 - 3782
Database
ISI
SICI code
0040-4039(20010604)42:23<3779:GDANCO>2.0.ZU;2-1
Abstract
Synthetic procedures have been developed to attach the nitric oxide releasi ng diazeniumdiolate functional groups [N(O)NO](-) to a carbohydrate unit. T hese glycosylated diazeniumdiolates exhibited significantly improved stabil ity as compared to their parent diazeniumdiolate salts, yet they could read ily release nitric oxide upon activation by glycosidases. Preliminary antit umor screen assay demonstrated that this class of compounds had antitumor a ctivity. (C) 2001 Published by Elsevier Science Ltd.