Synthesis of bridged analogs of epibatidine. 3-chloro-5,7,8,9,9a,10-hexahydro-7,10-methanopyrrolo[1,2-b]-2,6-naphthyridine and 2-chloro-5,5a,6,7,8,10-hexahydro-5,8-methanopyrrolo[2,1-b]-1,7-naphthyridine

Authors
Brieaddy, LE Mascarella, SW Navarro, HA Atkinson, RN Damaj, MI Martin, BR Carroll, FI
Citation
Le. Brieaddy et al., Synthesis of bridged analogs of epibatidine. 3-chloro-5,7,8,9,9a,10-hexahydro-7,10-methanopyrrolo[1,2-b]-2,6-naphthyridine and 2-chloro-5,5a,6,7,8,10-hexahydro-5,8-methanopyrrolo[2,1-b]-1,7-naphthyridine, TETRAHEDR L, 42(23), 2001, pp. 3795-3797
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
23
Year of publication
2001
Pages
3795 - 3797
Database
ISI
SICI code
0040-4039(20010604)42:23<3795:SOBAOE>2.0.ZU;2-A
Abstract
The synthesis of conformationally locked analogs of epibatidine are describ ed in which the key step is an intramolecular reductive palladium-catalyzed Heck-type coupling. (C) 2001 Elsevier Science Ltd. All rights reserved.