Expeditious preparation of 2-substituted quinolines

Authors
Fakhfakh, MA Franck, X Fournet, A Hocquemiller, R Figadere, B
Citation
Ma. Fakhfakh et al., Expeditious preparation of 2-substituted quinolines, TETRAHEDR L, 42(23), 2001, pp. 3847-3850
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
23
Year of publication
2001
Pages
3847 - 3850
Database
ISI
SICI code
0040-4039(20010604)42:23<3847:EPO2Q>2.0.ZU;2-6
Abstract
A library of 2-substituted quinolines was synthesized in solution from mixt ures of Grignard reagents and a quinolinium salt. Grignard reagents were pr epared in one pot, taking advantage of the entrainment method for their pre paration from unreactive alkyl halides. Then mixtures of 2-alkylquinolines were readily accessible for biological tests or separated by centrifugal-pa rtition chromatography (CPC) prior to the biological screening. (C) 2001 El sevier Science Ltd. All rights reserved.