Improved yields of meta-amination and symmetrical and unsymmetrical diamination of benzenes

Authors
Brown, GR Foubister, AJ Roberts, CA Wells, SL Wood, R
Citation
Gr. Brown et al., Improved yields of meta-amination and symmetrical and unsymmetrical diamination of benzenes, TETRAHEDR L, 42(23), 2001, pp. 3917-3919
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
23
Year of publication
2001
Pages
3917 - 3919
Database
ISI
SICI code
0040-4039(20010604)42:23<3917:IYOMAS>2.0.ZU;2-7
Abstract
Much higher yields were found after shorter reaction times for the meta-sub stituted amination of benzenes in DMPU with microwave heating in a sealed t ube (180 degreesC. 5 h). e.g. piperidine and m-fluorobenzonitrile 1 gave th e m-substituted 3 in 92% yield. These modified reaction conditions also aff orded a new synthesis of unsymmetrical diamines in > 80% yield. (C) 2001 El sevier Science Ltd. All rights reserved.