Grob-type fragmentation of N-alkyl-2-cyano-5-bromopiperidines to unsaturated imidoyl cyanides

Authors
Alonso, ER Tehrani, KA Boelens, M Knight, DW Yu, V De Kimpe, N
Citation
Er. Alonso et al., Grob-type fragmentation of N-alkyl-2-cyano-5-bromopiperidines to unsaturated imidoyl cyanides, TETRAHEDR L, 42(23), 2001, pp. 3921-3923
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
23
Year of publication
2001
Pages
3921 - 3923
Database
ISI
SICI code
0040-4039(20010604)42:23<3921:GFONTU>2.0.ZU;2-4
Abstract
2-Cyano-5-bromopiperidines. derived from the stereoselective addition of cy anide to 5-bromomethyl-l-pyrrolinium salts, underwent a Grob fragmentation by reaction with sodium hydride in dimethylformamide, affording unsaturated imidoyl cyanides. (C) 2001 Elsevier Science Ltd. All rights reserved.