Approaches to 2-substituted chroman-4-ones: synthesis of (-)-pinostrobin

Authors
Hodgetts, KJ
Citation
Kj. Hodgetts, Approaches to 2-substituted chroman-4-ones: synthesis of (-)-pinostrobin, TETRAHEDR L, 42(22), 2001, pp. 3763-3766
Citations number
42
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
22
Year of publication
2001
Pages
3763 - 3766
Database
ISI
SICI code
0040-4039(20010528)42:22<3763:AT2CSO>2.0.ZU;2-M
Abstract
Two approaches to optically active 2-substituted chroman-4-ones are describ ed. The first utilized the oxidation of a preformed chroman ring and the se cond an intramolecular Mitsunobu cyclization. The methodology was applied t o the synthesis of the biologically active natural product (-)-pinostrobin (18). (C) 2001 Elsevier Science Ltd. All rights reserved.