Iodine deficiency is the leading cause of preventable mental retardation. U
niversal salt iodization (USI), calling for all salt used in agriculture, f
ood processing, catering and household to be iodized, is the agreed strateg
y for achieving iodine sufficiency. This article reviews published informat
ion on programs for the sustainable elimination of the iodine deficiency di
sorders and reports new data on monitoring and impact of salt iodization pr
ograms at the population level. Currently, 68% of households from areas of
the world with previous iodine deficiency have access to iodized salt, comp
ared to less than 10% a decade ago. This great achievement, a public health
success unprecedented in the field of noncommunicable diseases, must be be
tter recognized by the health sector, including thyroidologists. On the oth
er hand, the managers and sponsors of programs of iodized salt must appreci
ate the continuing need for greatly improved monitoring and quality control
. For example, partnership evaluation of iodine nutrition using the ThyroMo
bil model in 35,223 schoolchildren at 378 sites of 28 countries has shown t
hat many previously iodine deficient parts of the world now have median uri
nary iodine concentrations well above 300 mug/L, which is excessive and car
ries the risk of adverse health consequences. The elimination of iodine def
iciency is within reach but major additional efforts are required to cover
the whole population at risk and to ensure quality con h ol and sustainabil
ity.