Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection

Electrophysiological recording demonstrated that visuo-tectal projections a re topographically organised after optic nerve regeneration in aged Xenopus laevis. H-3-thymidine autoradiography confirmed previous reports [Taylor, Lack, & Easter, fur. Journal of Neuroscience 1 (1989) 626-638] that cell di vision had already ceased at the retinal ciliary margin. The results demons trate that, contrary to a previous suggestion [Holder & Clarke, Trends in N euroscience 11 (1988) 94-99], continued neurogenesis is not a pre-requisite for the re-establishment of appropriate connections with target cells. (C) 2001 Elsevier Science Ltd. All rights reserved.