This case report describes a two-year-old red and white East Flemish cow wi
th an aggressive angiomyxoma (AA). The cow was presented for examination be
cause of vague complaints: dullness, loss of weight, diarrhea. Rectal exami
nation revealed the presence of multiple large, undefinable masses in the p
elvic cavity. The cow died the day after the clinical examination and was a
utopsied. The histopathological examination revealed an aggressive angiomyx
oma. This is, to the best of our knowledge, the first description of an AA
in animals.