Efficient synthesis of chiral isoquinoline and pyrido[1,2-b]isoquinoline derivatives via intramolecular Heck reactions

Authors
Sanchez-Sancho, F Mann, E Herradon, B
Citation
F. Sanchez-sancho et al., Efficient synthesis of chiral isoquinoline and pyrido[1,2-b]isoquinoline derivatives via intramolecular Heck reactions, ADV SYNTH C, 343(4), 2001, pp. 360-368
Citations number
77
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ADVANCED SYNTHESIS & CATALYSIS
ISSN journal
16154150 → ACNP
Volume
343
Issue
4
Year of publication
2001
Pages
360 - 368
Database
ISI
SICI code
1615-4150(200105)343:4<360:ESOCIA>2.0.ZU;2-#
Abstract
The palladium(0)-catalyzed reaction of derivatives of gamma -amino-alpha, b eta -unsaturated esters bearing an N-(2-iodobenzoyl) substituent results in an intramolecular Heck reaction, the outcome of which depends on the struc ture of the substrate as well as on the experimental conditions. The method ology developed has been applied to the efficient syntheses of chiral isoqu inoline and pyrido[1,2-b] isoquinoline derivatives.