Vitamin supplement use and fatal non-Hodgkin's lymphoma among US men and women

The authors evaluated the association between use of individual supplements of vitamins A, C, and E only and multivitamins and fatal non-Hodgkin's lym phoma in a large prospective mortality study of US men and women. During 14 years of follow-up (1982-1996), 1,571 non-Hodgkin's lymphoma deaths among 508,351 men and 1,398 non-Hodgkin's lymphoma deaths among 676,306 women wer e documented. Long-term regular use of individual supplements of vitamins A , C, and E only and multivitamins was unrelated to fatal non-Hodgkin's lymp homa among either men or women. The multivariate relative risks for men who used supplements for 10 or more years were 1.03 (95% confidence interval ( CI): 0.54, 2.00) for vitamin A supplements, 1.04 (95% CI: 0.78, 1.39) for v itamin C supplements, 1.06 (95% CI: 0.74, 1.51) for vitamin E supplements, and 1.14 (95% CI: 0.92, 1.40) for multivitamins. The multivariate relative risks for women who used supplements for 10 or more years were 1.40 (95% CI : 0.77, 2.54) for vitamin A supplements, 1.19 (95% CI: 0.89, 1.60) for vita min C supplements, 1.27 (95% CI: 0.87, 1.84) for vitamin E supplements, and 1.21 (95% CI: 0.98, 1.50) for multivitamins. All associations became weake r when vitamin supplements were mutually adjusted. These findings do not su pport an important relation between long-term regular use of individual sup plements of vitamins A, C, and E only and multivitamins and fatal non-Hodgk in's lymphoma.