Functional role of a glycolipid in directional movements of neurons

Migration of neurons from their site of origin to their final destination i s a critical and universal step in the formation of the complex structure o f the nervous system. The migratory process is thought to be governed in pa rt by generically and epigenetically defined sequences of signals which are interpreted by migrating cells. The molecular mechanisms that underlie neu ronal migration have been the subject of intense investigation. As in other developmental processes, many molecules must participate in neuronal migra tion. Some molecules, such as cell adhesion molecules and motor proteins, m ay contribute to discrete steps in the migration act; others, like extracel lular signaling molecules, may regulate the activation and/or termination o f the migration program. In this article we review findings from our group that demonstrate the functional role(s) of a specific glycolipid in neurona l migration and neurite outgrowth ill the developing and adult nervous syst em.