Rj. Stratta et al., A prospective comparison of simultaneous kidney-pancreas transplantation with systemic-enteric versus portal-enteric drainage, ANN SURG, 233(6), 2001, pp. 740-751
Objective
To compare pancreas transplantation with systemic-enteric (SE) versus porta
l-enteric (PE) drainage in a prospective fashion.
Summary Background Data
To improve the physiology of pancreas transplantation, the authors develope
d a new technique of portal venous delivery of insulin and enteric drainage
of the exocrine secretions.
Methods
During a 26-month period, the authors prospectively alternated 54 consecuti
ve simultaneous kidney and pancreas transplants to either SE (n = 27) or PE
(n = 27) drainage. The two groups were well matched for numerous character
istics. Maintenance immunosuppression in both groups consisted tacrolimus,
mycophenolate mofetil, and steroids.
Results Patient survival rates were 93% SE versus 96% PE; kidney graft surv
ival rates were 93% in both groups. Pancreas trans plantation survival (com
plete insulin independence) was 74% after SE versus 85% after PE drainage w
ith a mean follow-up of 17 months. The mean length of initial hospital stay
was 12.4 days in the SE group and 12.8 days in the PE group. The SE group
was characterized by a slight increase in the number of readmissions. The i
ncidences of acute rejection (33%) and major infection (52%) were similar i
n both groups. The incidence of intraabdominal infection was slightly highe
r in the SE group. However, the early relaparotomy rate was similar between
groups. The composite endpoint of no rejection, graft loss, or death was a
ttained in 56% of SE versus 59% of PE patients.
Conclusions These results suggest that simultaneous kidney and pancreas tra
nsplantation with SE or PE drainage can be performed with comparable short-
term outcomes.