Phenylamides of 1-phenyl (or methyl)-5-benzamidopyrazole-4-carboxylic acidas vratizolin analogs with analgesic and antiinflammatory activities

A number of phenylamides of 5 -benzamidopyrazole-4-carboxylic acid were pre pared in 50-80 % yields from 1-phenyl (or methyl)-6-phenylpyrazolo[3,4-d] 1 ,3-oxazin-4(1 H)-ones and aniline derivatives. All the compounds were teste d for their analgesic and antiinflammatory activities, as well as for their ulcerogenic potential and acute toxicity. Some derivatives, when compared to phenylbutazone, proved more active in the tests for analgesic and antiex udative activities, but less active in the carrageenin paw oedema test. The compounds proved to posses marginal or no ulcerogenic effect, as well as l ow systemic toxicity.