I. Kostova et al., Synthesis, physicochemical characterization, and cytotoxic screening of new zirconium complexes with coumarin derivatives, ARCH PHARM, 334(5), 2001, pp. 157-162
Zirconium complexes of mendiaxon, warfarin, coumachlor, and niffcoumar have
been synthesized by reaction of the ligands with zirconium chloride in sto
ichiometric ratio 1:2. The formation of the complexes has been proved on th
e basis of elemental analysis, IR-spectroscopy. IH-NMR spectroscopy, and th
ermal studies. Differential thermal analyses and thermogravimetric analyses
have been applied to study the compositions of the new complexes. It is co
ncluded that the lactone- and the keto-carbonyl groups of warfarin, coumach
lor, and niffcoumar are bonded to the metal ion as bidentate ligands, but m
endiaxon is bonded as monodentate ligand. Cytotoxic screening by MTT-assay
was carried out. Among these compounds the zirconium complex of mendiaxon s
howed highest cytotoxic activity against human promyelocytic leukemic HL-60
cells. The inorganic salt was found to be active against this cell line.