Synthesis of imidazo[4,5-d]oxazolo[3,4-a]pyridines. New heterocyclic analogues of lignans

Authors
Madrigal, B Puebla, P Caballero, E Pelaez, R Gravalos, DG Medarde, M
Citation
B. Madrigal et al., Synthesis of imidazo[4,5-d]oxazolo[3,4-a]pyridines. New heterocyclic analogues of lignans, ARCH PHARM, 334(5), 2001, pp. 177-179
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIV DER PHARMAZIE
ISSN journal
03656233 → ACNP
Volume
334
Issue
5
Year of publication
2001
Pages
177 - 179
Database
ISI
SICI code
0365-6233(200105)334:5<177:SOINHA>2.0.ZU;2-H
Abstract
The preparation of new analogues of lignans carrying an imidazole ring has been achieved Starting from L-histidinol, cis and trans stereoisomers have been obtained. The synthesized products lack the cytotoxicity displayed by related podophyllotoxins and azatoxin.