Bone status in cystic fibrosis

Aim - To investigate bone mineral status of children with cystic fibrosis ( CF). Methods - In 29 children with CF and 49 matched controls, bone mineral cont ent (BMC), projected bone area (BA), and areal bone mineral density (BMD) o f the whole body, total hip, and lumbar spine (L1-L4) were measured using d ual energy x ray absorptiometry. The BMC values at each site were adjusted for BA, height, and weight. At the lumbar spine, the bone mineral apparent density (BMAD) was calculated by dividing the BMC by the estimated volume, derived from BA. Vertebral (T12-L3) trabecular bone mineral density (vTBMD) was measured using quantitative computed tomography in children with CF. C alcaneal broadband ultrasound attenuation (BUA) was measured in CF patients and controls using quantitative ultrasound. The disease severity of CF chi ldren was evaluated by the Schwachman-Kulczycki (SK) score. Results - The mean BUA, whole body and regional BA, adjusted BMC, and areal BMD of children with CF were not different from those of controls. The mea n BMAD of the lumbar spine was reduced in CF patients compared with control s, whereas the mean vTBMD standard deviation scores were significantly high er in CF patients. The median SK score of the CF group was 81 (range 42-100 ), indicating that as a group our CF patient population had relatively mild disease. Conclusion - The normal vertebral BMC, decreased BMAD, and higher vTBMD sug gests that the vertebral cortical thickness or density might be reduced in CF subjects. The overall bone mineral status of CF children with relatively mild disease was not different from size matched controls.