Development of the MEDOS/HIA DeltaStream extracorporeal rotary blood pump

The DeltaStream blood pump has been developed for extracorporeal circulatio n with one focus on potential integration into simplified bypass systems (S BS). Its small size and an embedded electric motor are the basic pump prope rties. A variation of the impeller design has been performed to optimize hy draulic and hematologic characteristics. A simple impeller design was devel oped which allows flow and pressure generation for cardiopulmonary bypass a pplications. The option of a pulsatile flow mode for ventricular assist dev ice applications also was demonstrated in vitro. Impeller washout holes wer e implemented to improve nonthrombogenicity. The pump was investigated for potential thermal hazards for blood caused by the integrated electric motor . It could be demonstrated that there is no thermal risk associated with th is design. Durability tests were performed to assess the lifetime of the pu mp especially with regard to the incorporated polymeric seal. Seal lifetime s of up to 28 days were achieved using different blood substitutes. In anim al tests using either the pump as a single device or in an SBS setup, bioco mpatibility, low hemolysis, and nonthrombogenicity were demonstrated. In su mmary, the DeltaStream pump shows great potential for different extracorpor eal perfusion applications. Besides heart-lung machine and SBS applications , ventricular assist and extracorporeal membrane oxygenation up to several days also appear promising as potential applications.