Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects

Authors
Li, YP Pei, YY Zhou, ZH Zhang, XY Gu, ZH Ding, J Zhou, JJ Gao, XJ Zhu, JH
Citation
Yp. Li et al., Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects, BIOL PHAR B, 24(6), 2001, pp. 662-665
Citations number
31
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
24
Issue
6
Year of publication
2001
Pages
662 - 665
Database
ISI
SICI code
0918-6158(200106)24:6<662:SPNATN>2.0.ZU;2-M
Abstract
The objective of this study was to investigate the pharmacokinetics and in vivo anti-tumor effect of recombinant human tumor necrosis factor-a (rHuTNF -alpha) encapsulated in poly(methoxypolyethyleneglycol cyanoacrylate-co-n-h exadecyl cyanoacrylate) (PEG-PHDCA) nanoparticles, Our experimental results showed that PEG-PHDCA nanoparticles could extend the half-life of rHuTNF-a lpha to 7.42 h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-alpha in tumor. Compare d with PHDCA nanoparticles and free rHuTNF-alpha PEG-PHDCA nanoparticles lo aded with rHuTNF-alpha showed higher antitumor potency at the same dose, wh ich might be related to its higher accumulation in tumor tissues and longer plasma circulation time. Therefore, PEG-PHDCA nanoparticles could be an ef fective carrier for rHuTNF-alpha.