Synthesis of potent and selective dopamine D-4 antagonists as candidate radioligands

Authors
Huang, YY Kegeles, LS Bae, SA Hwang, DR Roth, BL Savage, JE Laruelle, M
Citation
Yy. Huang et al., Synthesis of potent and selective dopamine D-4 antagonists as candidate radioligands, BIOORG MED, 11(11), 2001, pp. 1375-1377
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
11
Year of publication
2001
Pages
1375 - 1377
Database
ISI
SICI code
0960-894X(20010604)11:11<1375:SOPASD>2.0.ZU;2-P
Abstract
A series of dopamine D-4 antagonists was synthesized and evaluated as poten tial candidates for development as positron emission tomography (PET) radio ligands. All new compounds display high affinity and selectivity for the D- 4 receptors and compounds 5b, 5d, and 5e were identified as candidates for radioligand development. (C) 2001 Elsevier Science Ltd. All rights reserved .