Structure-activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells

Authors
Young, DH Tice, CM Michelotti, EL Roemmele, RC Slawecki, RA Rubio, FM Rolling, JA
Citation
Dh. Young et al., Structure-activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells, BIOORG MED, 11(11), 2001, pp. 1393-1396
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
11
Year of publication
2001
Pages
1393 - 1396
Database
ISI
SICI code
0960-894X(20010604)11:11<1393:SROPAB>2.0.ZU;2-T
Abstract
Phenylcyclohexenes (PCHs) [e.g., trans-4-nitro-5-(2,3,4-trimethoxyphenyl) c yclohexene, 2d] were found to bind weakly to the colchicine site of bovine tubulin, but are the first mimics of colchicine found to have high activity towards plant cells. Structure-activity relationships for PCHs and bipheny l AC-ring analogues of colchicine (e.g., 2,3,4,4'-tetramethoxy-2'-methyl-1, 1'-biphenyl, 3e) are discussed. (C) 2001 Elsevier Science Ltd. All rights r eserved.