Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

Authors
Dhanak, D Christmann, LT Darcy, MG Jurewicz, AJ Keenan, RM Lee, J Sarau, HM Widdowson, KL White, JR
Citation
D. Dhanak et al., Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1, BIOORG MED, 11(11), 2001, pp. 1441-1444
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
11
Year of publication
2001
Pages
1441 - 1444
Database
ISI
SICI code
0960-894X(20010604)11:11<1441:DOPASP>2.0.ZU;2-G
Abstract
The discovery of a series of phenylalanine derived CCR3 antagonists is repo rted. Parallel, solution-phase library synthesis has been utilized to delin eate the structure-activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists. (C) 2001 Elsevier Science Ltd. All rig hts reserved.