Inhibitors of the bacterial cell wall biosynthesis enzyme MurC

Authors
Reck, F Marmor, S Fisher, S Wuonola, MA
Citation
F. Reck et al., Inhibitors of the bacterial cell wall biosynthesis enzyme MurC, BIOORG MED, 11(11), 2001, pp. 1451-1454
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
11
Year of publication
2001
Pages
1451 - 1454
Database
ISI
SICI code
0960-894X(20010604)11:11<1451:IOTBCW>2.0.ZU;2-X
Abstract
A series of phosphinate transition-state analogues of the L-alanine adding enzyme (MurC) of bacterial peptidoglycan biosynthesis was prepared and test ed as inhibitors of the Escherichia coli enzyme. Compound 4 was identified as a potent inhibitor of MurC from Escherichia coli with an IC50 Of 49 nM. (C) 2001 Elsevier Science Ltd. All rights reserved.