Fine tuning of physico-chemical parameters to optimise a new series of novobiocin analogues

Authors
Schio, L Chatreaux, F Loyau, V Murer, M Ferreira, A Mauvais, P Bonnefoy, A Klich, M
Citation
L. Schio et al., Fine tuning of physico-chemical parameters to optimise a new series of novobiocin analogues, BIOORG MED, 11(11), 2001, pp. 1461-1464
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
11
Year of publication
2001
Pages
1461 - 1464
Database
ISI
SICI code
0960-894X(20010604)11:11<1461:FTOPPT>2.0.ZU;2-E
Abstract
A novel series of novobiocin analogues has been synthesised by removing the lipophilic aryl chain in novobiocin and introducing an amino substituent. The structural modifications have been dictated by the control of lipophili city and the dissociation constant of the resulting compounds. Antibacteria l activity of the new coumarin derivatives could be correlated with the amo unt of uncharged form in physiological conditions. (C) 2001 Elsevier Scienc e Ltd. All rights reserved.