Arylsulphonyl hydroxamic acids: Potent and selective matrix metalloproteinase inhibitors

Authors
Baxter, AD Bhogal, R Bird, J Keily, JF Manallack, DT Montana, JG Owen, DA Pitt, WR Watson, RJ Wills, RE
Citation
Ad. Baxter et al., Arylsulphonyl hydroxamic acids: Potent and selective matrix metalloproteinase inhibitors, BIOORG MED, 11(11), 2001, pp. 1465-1468
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
11
Year of publication
2001
Pages
1465 - 1468
Database
ISI
SICI code
0960-894X(20010604)11:11<1465:AHAPAS>2.0.ZU;2-9
Abstract
A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and whic h demonstrate potent in vivo activity in models of arthritis and cancer. (C ) 2001 Elsevier Science Ltd. All rights reserved.