Selective breeding of two rat lines differing in sensitivity to GHB and baclofen

Authors
Colombo, G Lobina, C Agabio, R Brunetti, G Diaz, G Littera, M Melis, S Pani, M Reali, R Serra, S Vacca, G Carai, MAM Gessa, GL
Citation
G. Colombo et al., Selective breeding of two rat lines differing in sensitivity to GHB and baclofen, BRAIN RES, 902(1), 2001, pp. 127-130
Citations number
12
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
902
Issue
1
Year of publication
2001
Pages
127 - 130
Database
ISI
SICI code
0006-8993(20010525)902:1<127:SBOTRL>2.0.ZU;2-U
Abstract
Two Wistar-derived rat lines, one sensitive (GHB-S) and the other resistant (GHB-R) to the anesthetic effect of gamma -hydroxybutyric acid (GHB), have been selectively bred. GHB-S and GHB-R rats were also sensitive and resist ant, respectively, to the anesthetic effect of baclofen, the prototype GABA , receptor agonist, suggesting that they may be useful to elucidate not onl y the role of endogenous GHB but also that of GABA, receptors in sleep and anesthesia. (C) 2001 Elsevier Science B.V. All rights reserved.