Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation

Authors
Roy, HK Karoski, WJ Ratashak, A Smyrk, TC
Citation
Hk. Roy et al., Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation, BR J CANC, 84(10), 2001, pp. 1412-1416
Citations number
23
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
84
Issue
10
Year of publication
2001
Pages
1412 - 1416
Database
ISI
SICI code
0007-0920(20010518)84:10<1412:COITBN>2.0.ZU;2-5
Abstract
Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumet one, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with con comitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention. (C) 2001 Cancer Research Campaign.