Molecular cytogenetic characterization of an acquired minute supernumerarymarker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia

Authors
Starke, H Raida, M Trifonov, V Clement, JH Loncarevic, IF Heller, A Bleck, C Nietzel, A Rubtsov, N Claussen, U Liehr, T
Citation
H. Starke et al., Molecular cytogenetic characterization of an acquired minute supernumerarymarker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia, BR J HAEM, 113(2), 2001, pp. 435-438
Citations number
12
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
113
Issue
2
Year of publication
2001
Pages
435 - 438
Database
ISI
SICI code
0007-1048(200105)113:2<435:MCCOAA>2.0.ZU;2-W
Abstract
A case of chronic myelogenous leukaemia (CML) in a 48-year-old man is repor ted. To the best of our knowledge, this is the first report of a Philadelph ia-negative Chit with an acquired small supernumerary marker chromosome (SM C) 11 as the sole abnormality. The derivative chromosome 11 was studied in detail using molecular cytogenetic methods; fluorescence in situ hybridizat ion (FISH) using centromere- and region-specific probes for chromosome 11, microdissection, micro-comparative genomic hybridization (micro-CGH) and th e recently developed multicolour banding (MCB) technique. The acquired SMC was determined to be a ring chromosome that can be described as r(11)(:p11. 2-->q13.1::q14:).