Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: perpetuation by granulocyte colony-stimulating factor

Authors
Pocock, CF Lucas, GF Giles, C Vassiliou, G Cwynarski, K Rezvani, K Apperley, JF Goldman, JM
Citation
Cf. Pocock et al., Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: perpetuation by granulocyte colony-stimulating factor, BR J HAEM, 113(2), 2001, pp. 483-485
Citations number
11
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
113
Issue
2
Year of publication
2001
Pages
483 - 485
Database
ISI
SICI code
0007-1048(200105)113:2<483:INAWAN>2.0.ZU;2-3
Abstract
A case of immune neutropenia following unrelated stem cell transplantation for chronic myeloid leukaemia is described. The neutropenia developed follo wing herpes tester viral infection and was associated with antibodies to th e human neutrophil antigen (HNA)-2a (formerly known as NB1). The neutropeni a was prolonged, profound and unresponsive to granulocyte colony-stimulatin g factor (GCSF). The neutrophil count recovered after GCSF was discontinued . HNA-2a has been reported to be upregulated following GCSF administration. In the present case, it appears that the immune neutropenia may have been perpetuated by GCSF administration.