Molecular (de)regulation and cancer: new therapeutic strategies

The considerable progress of molecular biology within the past twenty Years has permitted a more and more detailed characterization of the molecular m echanisms regulating cell proliferation. The corollary to these discoveries has been the identification of different deregulations yielding to cell tr ansformation and cancer. The goal of this review is to present new therapeu tic tools that stemmed from the now well understood logic underlying cell t ransformation. These tools, based on the intimate understanding of signaliz ation pathway aim at restoring the molecular controls which had been abroga ted during the process of cell transformation. We Present a survey of these new proposed therapeutic strategies. These neu, approaches will probably a llow the clinician, in the near future, to combine traditional therapies wi th more targeted ones, and thus to limit side effects often associated with classical cancer therapies, white improving the overall effect of the trea tment