Construction of multivalent sialyl Le(x) from the type Ia group B Streptococcus capsular polysaccharide

Authors
Zou, W Li, JJ Larocque, S Jennings, HJ
Citation
W. Zou et al., Construction of multivalent sialyl Le(x) from the type Ia group B Streptococcus capsular polysaccharide, CARBOHY RES, 332(3), 2001, pp. 249-255
Citations number
45
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215 → ACNP
Volume
332
Issue
3
Year of publication
2001
Pages
249 - 255
Database
ISI
SICI code
0008-6215(20010604)332:3<249:COMSLF>2.0.ZU;2-E
Abstract
The type Ia group B Streptococcus (GBSIa) capsular polysaccharide was speci fically degraded by partial Smith oxidation of 2,3-diol of the Glc in the b ackbone to fragments representing asialo core repeating units. Sialylation of these oligomers furnished GBSIa multiple repeating units. One, two and t hree repeating units of GBSIa were obtained pure, and the higher oligomers were obtained as mixtures. After enzymatic fucosylation oligosaccharides ca rrying bivalent, trivalent and other multivalent sialyl Le(x) epitopes pres ented as appendages on an oligolactoside scaffold were obtained. (C) 2001 E lsevier Science Ltd. All rights reserved.