Effect of a low-fluoride-content. two-component rinse on fluoride uptake and on de- and remineralization of enamel lesions: An in vitro study

The effect of calcium (Ca) concentrations and added ethanol on fluoride (F) depositions by experimental two-component rinses, each consisting of a Ca- containing and an F-containing component, was evaluated in an in vitro syst em. Among the tested rinses, a 3 mmol/l F two-component rinse with 200 mmol /l Ca and 10% v/v ethanol was found to produce the greatest F deposition re lative to the F concentration in the rinse. Specifically, this rinse produc ed an F deposition that was about 7 times gi eater than a conventional 13.2 -mmol/l sodium fluoride (NaF) rinse. In a second experiment, an in vitro pH cycling model was used to evaluate the potential anti-caries effects of 4 rinses: (1) placebo rinse (no F), (2) 13.2-mmol/l NaF rinse, (3) 52.6-mmol/ l NaF rinse, and (4) the 3-mmol/l F two-component rinse in a 7-day in vitro pH cycling model. The changes in lesion mineral contents, delta(DeltaZ), a s assessed by quantitative microradiographic measurements, were as follows [mean +/- standard deviation, n = 10]: (1) 72.5 +/- 10.2 mum, (2) 43.4 +/- 5.6 mum, (3) 17.3 +/- 10.2 mum and (4) 45.3 +/-5.2 mum. These results showe d that the 3-mmol/l F two-component rinse produced the same (p >0.05) prote ction against demineralization as did the 13.2-mmol/l NaF rinse which had 4 times the fluoride content. The results suggest that it is possible to for mulate an effective low-F two-component rinse. Copyright (C) 2001 S. Karger AG, Basel.