Antioxidative glucosides from the fruits of Ligustrum lucidum

The ethanol extract of the fruits of Ligustrum lucidum was shown to have in hibitory effects on the hemolysis of red blood cells induced by 2.2 ' -azo- bis-(2-amidinopropane) dihydrochloride, Bioassay-guided analysis led to the isolation of ten secoiridoid glucosides, Two of them were new, lucidumosid es C and D. Their structures were elucidated by spectroscopic methods. The other eight compounds were identified as oleoside dimethyl ester, ligus-tro side, oleuropein, nuezhenide, isonuezhenide, neonuezhenide, lucidumoside A and lucidumoside B, Five compounds, oleoside dimethyl ester, oleuropein, ne onuezhenide, lucidumoside B and lucidumoside C, exhibited strong antioxidan t effect against hemolysis of red blood cells induced by free radicals.