PHARMACOKINETICS AND DOSAGE REGIMEN OF AMIKACIN IN FEBRILE COW CALVES

Disposition kinetics and dosage regimen of amikacin were investigated in experimentally induced febrile male cow calves. Fever was induced w ith E. coil endotoxin (1 mu g.kg, i/v) and after induction of fever, a mikacin was administered (10 mg/kg, i/v). At 1 min, the peak plasma le vel of amikacin was 133.6 +/- 1.96 mu g/ml and the minimum therapeutic concentration was maintained up to 12 hr. The distribution half-lives in peripheral compartments 1 and 2 were 0.06 +/- 0.006 hr and 0.68 +/ - 0.03 hr, respectively. The elimination half-life and volume of distr ibution were 4.10 +/- 0.31 hr and 0.35 +/- 0.04 L/kg respectively. The values of total body clearance (Cl-B) and T/P ratio were 0.05 +/- 0.0 1 L/kg hr and 6.21 +/- 0.78 respectively. To maintain the minimum ther apeutic plasma concentration, the appropriate dosage regimen of amikac in in febrile cow calves would be 6 mg/kg followed by 5 mg/kg at 12 hr intervals.