Cancer chemotherapy - ribonucleases to the rescue

Authors
Leland, PA Raines, RT
Citation
Pa. Leland et Rt. Raines, Cancer chemotherapy - ribonucleases to the rescue, CHEM BIOL, 8(5), 2001, pp. 405-413
Citations number
78
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CHEMISTRY & BIOLOGY
ISSN journal
10745521 → ACNP
Volume
8
Issue
5
Year of publication
2001
Pages
405 - 413
Database
ISI
SICI code
1074-5521(200105)8:5<405:CC-RTT>2.0.ZU;2-W
Abstract
Ribonucleases, once dismissed as uninteresting digestive enzymes, have been shown to have remarkable biological activities. Onconase (R), from the Nor thern leopard frog, is currently in clinical trials as a cancer chemotherap eutic. Recent research has revealed some key factors responsible for the cy totoxicity of ribonucleases, and may lead to a new class of drugs. (C) 2001 Published by Elsevier Science Ltd.