Antituberculous activity of norfloxacin Mannich bases with isatin derivatives

Authors
Pandeya, SN Sriram, D Yogeeswari, P Ananthan, S
Citation
Sn. Pandeya et al., Antituberculous activity of norfloxacin Mannich bases with isatin derivatives, CHEMOTHERA, 47(4), 2001, pp. 266-269
Citations number
9
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
CHEMOTHERAPY
ISSN journal
00093157 → ACNP
Volume
47
Issue
4
Year of publication
2001
Pages
266 - 269
Database
ISI
SICI code
0009-3157(200107/08)47:4<266:AAONMB>2.0.ZU;2-B
Abstract
pounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 12.5 mug/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The lower t han 6.25 mug/ml.