Objective: The study tested the hypothesis: that females who sustain stress
fractures of cancellous bone have decreased bone density.
Design: A retrospective, controlled, cross-sectional study.
Setting: The setting of the study was a tertiary care center for Women's Sp
orts Medicine.
Patients: 20 female patients under the age of 40 who had suffered a stress
fracture and who had a positive diagnostic study (radiograph, bone scan, or
magnetic resonance imaging) were included in the study.
Interventions: Patients who had a positive diagnostic study (radiograph, bo
ne scan, or magnetic resonance imaging) for the diagnosis of stress fractur
e also underwent dual energy X-ray absorptiometry (DEXA) scans.
Main Outcome Measure: Bone density measured by the DEXA scan, as defined by
the World Health Organization criteria for osteopenia (greater than one st
andard deviation from the standard age-matched control).
Results: 8 of 9 patients with cancellous stress fractures had DEXA scans in
dicating osteopenia while only 3 of 11 patients with stress fractures of co
rtical bone had a scan indicating osteopenia (p = 0.01).
Conclusions: A cancellous stress fracture in a female may be a warning sign
of early onset osteopenia. We recommend that young females who have docume
nted stress fractures of cancellous bone or cortical bone (with risk factor
s for osteopenia) undergo bone density evaluation.