Of flies and men - studying human disease in Drosophila

Authors
Bernards, A Hariharan, IK
Citation
A. Bernards et Ik. Hariharan, Of flies and men - studying human disease in Drosophila, CUR OP GEN, 11(3), 2001, pp. 274-278
Citations number
49
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
274 - 278
Database
ISI
SICI code
0959-437X(200106)11:3<274:OFAM-S>2.0.ZU;2-M
Abstract
During the past year, the Drosophila genome has been sequenced. More than 6 0% of genes implicated in human disease have Drosophila orthologues. Develo pments in RNA-mediated interference and homologous recombination have made 'reverse genetics' feasible in Drosophila. Conventional Drosophila genetics is being used increasingly to place human disease genes of unknown functio n in the context of functional pathways.