NF-kappa B signaling and human disease

Despite substantial progress in understanding the NF-kappaB signaling pathw ay, the connections between this pathway and human disease are only now bei ng elucidated. Genes that function within or upstream of the NF-kappaB path way have been found to cause four distinct disorders and two allelic condit ions. Investigation of these genes and disorders has brought significant in sight into the role of NF-kappaB in various aspects of physiological develo pment.