A case of giant extramammary Paget's disease of the genital area with squamous-cell carcinoma

Extramammary Paget's disease is a primary carcinoma with apocrine different iation that begins within the epidermis, Extramammary Paget's disease and s quamous-cell carcinoma (SCC) have different neoplastic origins and are diff erent both clinically and histologically. Until now the concurrence of extr amammary Paget's disease and SCC in the same area has not been reported to our knowledge. We report on a 76-year-old man with extramammary Paget's dis ease affecting a large region of the genital area with SCC within the same area. A skin biopsy specimen showed the coexistence of typical Paget's dise ase and highly differentiated SCC invading the dermis. Immunohistochemical staining of both cell types was completely different. Copyright (C) 2001 S. Karger AG, Basel.