Hyperkeratosis lenticularis perstans (Flegel's disease) - Lack of responseto treatment with tacalcitol and carcipotriol

Hyperkeratosis lenticularis perstans (HLP) or Flegel's disease is a rare de rmatosis characterized by asymptomatic hyperkeratotic papules predominantly located on the lower extremities. Lesional and non-lesional epidermis samp les were studied by light- and electron-microscopic examination. The main u ltrastructural finding was the presence of structurally altered Odland bodi es/membrane-coating granules. Different therapeutic options for HLP have be en reported, but none of the treatments was shown to be consistently effect ive. Here, we report on a patient with Flegel's disease who did respond to topical 5-fluorouracil, whereas topical Vitamin D-3 synthetics were ineffec tive. Copyright (C) 2001 S. Karger AG, Basel.