The discovery of a cystic lesion in the pancreas implies a challenge for th
e physician. Approximately 10% are cystic tumors, benign to highly malignan
t, or true cysts, showing all stages of cellular differentiation, from beni
gn to highly malignant tumors. Malignant cystic tumors are rare and compris
e only about 1% of all pancreatic malignancies, they are potentially curabl
e. Therefore, correct diagnosis and treatment of these lesions are of great
importance. It is usually not possible to separate a pseudocyst from a ben
ign cyst or a cystic tumor, but there are some signs and findings that coul
d be helpful in the clinical decision. The diagnosis of a cystic pancreatic
tumor requires different imaging techniques, including ultrasonography, co
mputerized tomography, magnetic resonance imaging, and magnetic resonance c
holangiopancreatography, but to distinguish a pseudocyst or a benign cyst f
rom a potentially malignant lesion can be very difficult. The usefulness of
blood tests and investigations of cyst fluid can be questionable. Today, s
urgical treatment of cystic pancreatic tumors can be performed with low mor
bidity. Therefore, we conclude that an active strategy with resection of cy
stic tumors of the pancreas should be recommended. Copyright (C) 2001 S. Ka
rger AG, Basel.