Significance of expression of CD54, CD25, proliferating cell antigens, andIgM in tumor cells and lymphocytes for their interactions in vitro

Authors
Berezhnaya, NM Spivak, SI Vinnichuk, YD Kovalchuk, EV Konovalenko, VF
Citation
Nm. Berezhnaya et al., Significance of expression of CD54, CD25, proliferating cell antigens, andIgM in tumor cells and lymphocytes for their interactions in vitro, EXP ONCOL, 23(1), 2001, pp. 66-70
Citations number
23
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
EXPERIMENTAL ONCOLOGY
ISSN journal
02043564 → ACNP
Volume
23
Issue
1
Year of publication
2001
Pages
66 - 70
Database
ISI
SICI code
0204-3564(200103)23:1<66:SOEOCC>2.0.ZU;2-Z
Abstract
The role of the expression of proliferating cell antigen, CD54, CD25, and I gM in the interaction of lymphocytes of distant and regional lymph nodes wi th tumor cells was studied upon analysis of MH-rabdomyosarcoma growth and m ethylcholanthrene-induced tumorigenesis. Antitumor activity of regional lym ph node lymphocytes was higher than antitumor activity of distant lymph nod e lymphocytes. Such an activity was more pronounced in case of transplantab le MH-rabdomyosarcoma. This antitumor activity correlated with expression o f CD54 and IgM on lymphocytes of mice with MH-rabdomyosarcoma and with prol iferating cell antigen expression on lymphocytes of mice with methylcholant hrene-induced tumors.