Many patients with microscopic colitis will respond to antidiarrheal medica
tions or to anti-inflammatory therapy with 5-aminosalicylates, although a f
ew require corticosteroids, Some patients do not tolerate corticosteroid si
de effects, and a small subset are dependent on or refractory to corticoste
roids, We report our experience with azathioprine and 6-mercaptopurine in p
atients with microscopic colitis.