Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor

Sertoli-Leydig cell tumors (SLCTs) represent a rare group of sex-cord strom al tumors of the ovary of unknown pathogenesis. We report a SLCT of interme diate differentiation with peritoneal recurrence and lymph node metastasis 12 months after removal, including cytogenetic analysis by comparative geno mic hybridization and fluorescence in situ hybridization, which showed tris omy 8 as sole unbalanced karyotypic aberration. Our results provide evidenc e that a simple numeric chromosomal abnormality in SLCT may be associated w ith a malignant phenotype and suggest that the molecular pathogenesis of SL CT may be different from ovarian granulosa-stromal cell tumors. Copyright ( C) 2001 by W.B. Saunders Company.