Aggravation of food-related behavior in an adolescent with Prader-Willi syndrome treated with fluvoxamine amd fluoxetine

Prader-Willi Syndrome is a congenital multisystem disorder, characterized b y a typical dysmorphism, mental retardation, hyperphagia due to insatiable appetite, and resultant morbid obesity. Psychiatric symptoms include obsess ions and temper tantrums. Method: Pharmacotherapy is experimental with a fe w reports of successful fluoxetine treatment. Results: We report an aggrava tion in the food-related symptoms and a consequent weight gain in an adoles cent with Prader-Willi syndrome, who was treated with fluvoxamine and fluox etine. (C) 2001 by John Wiley & Sons, Inc.