DEOXYPYRIDINOLINE AND OTHER BIOCHEMICAL M ARKERS OF BONE-RESORPTION IN DIFFERENT CONDITIONS

Collagen type 1 represents more than 90% of bone matrix. Therefore, qu antitation of collagen crosslinks, such as deoxypyridinoline, can prov ide information on bone resorption degree. An evaluation was made of d eoxypyridinoline as well as other bone markets, such as alkaline phosp hatase, tartrate resistant acid phosphatase, and hydroxyproline in pat ients with the diagnosis of osteoporosis, Paget's disease, hyperthyroi dism, and chronic renal failure on haemodyalisis or not. Deoxypyridino line levels were significantly increased in patients with osteoporosis , Paget's disease, and hyperthyroidism. Hydroxyproline levels were inc reased in patients with Paget's disease, and tartrate resistant acid p hosphatase was increased in all the entities studied. Deoxypyridinolin e can be a more sensitive marker than hydroxyproline, with some advant ages, such as its quantitation in a urine specimen and its high bone s pecificity. In patients with renal failure, tartrate resistant acid ph osphatase was the only biochemical marker of bone resorption with incr eased levels.