General anesthesia for interventional neuroradiology: Propofol versus isoflurane

Study Objective: To compare recovery of psychomotor and cognitive ability a fter isoflurane and propofol-based general anesthesia. Design: Prospective, blinded interventional study. Setting: University hospital. Patients: 24 ASA physical status I and II patients undergoing embolization procedures for intracranial vascular lesions. Interventions: Isoflurane ane sthesia or propofol anesthesia was given to patients. Measurements: Awakening time; early recovery (5 minutes, 15 minutes, 30 min utes) was assessed using orientation and Steward tests; medium recovery (30 minutes, 60 minutes, 120 minutes) was tested using Controlled World Associ ation (COWAT) and Digit Span tests; late recovery (4 hours, 24 hours) was a ssessed using a Verbal Learning and Memory Test and three subtests of a com puterized attention test battery. Main Results: Awakening time and early re covery of motor and respiratory function did not differ between groups, The propofol group scored worse in COWAT and Digit Span tests up to 60 minutes after anesthesia. Both groups showed an impairment of higher cognitive fun ctions up to 24 hours after anesthesia. Conclusions: Both isoflurane- and propofol-based anesthesia allow early ext ubation and recovery of basic psychomotor functions. More sophisticated tes ts show a decline of cognitive functions up to 24 hours after isoflurane- a s well as propofol-based anesthesia, Because both anesthetics show similar recovery of psychomotor functions after long duration anesthesia, other fac tors such as subjective well-being and costs may De considered when decidin g between these two anesthetics. (C) 2001 by Elsevier Science Inc.