Although biological agents have been used in warfare for centuries, several
events in the past decade have raised concerns that they could be used for
terrorism. Revelations about the sophisticated biological-weapons programs
of the former Soviet Union and Iraq have heightened concern that countries
with offensive-research programs, including those that sponsor internation
al terrorism, might assist in the proliferation of agents, culturing capabi
lity, and dissemination techniques, and might benefit in these undertakings
from the availability of skilled laboratory technicians. Release of sarin
nerve agent in the Tokyo subway system in 1995 by the Aum Shinrikyo cult de
monstrated that in the future terrorists might select unconventional weapon
s. Certain properties of biological pathogens may make them the ideal terro
rist weapon, including 1) ease of procurement, 2) simplicity of production
in large quantities at minimal expense, 3) ease of dissemination with low t
echnology, and 4) potential to overwhelm the medical system with large numb
ers of casualties. Dissemination of a biological agent would be silent, and
the incubation period allows a perpetrator to escape to great distances fr
om the area of release before the first ill persons seek medical care. Coun
termeasures include intelligence gathering, physical protection, and detect
ion systems. Medical countermeasures include laboratory diagnostics, vaccin
es, and medications for prophylaxis and treatment. Public health, medical,
and environmental health personnel need to have a heightened awareness, thr
ough education, about the threat from biological agents.