Evaluation of renal arteries with use of gadoterate meglumine-, CO2-, and iodixanol-enhanced DSA measurements versus histomorphometry in renal arteryrestenosis in rabbits
Af. Le Blanche et al., Evaluation of renal arteries with use of gadoterate meglumine-, CO2-, and iodixanol-enhanced DSA measurements versus histomorphometry in renal arteryrestenosis in rabbits, J VAS INT R, 12(6), 2001, pp. 747-752
PURPOSE: To experimentally evaluate gadolinium (Gd)-, carbon dioxide (CO2)-
, and iodixanol-enhanced digital subtraction angiography (DSA) versus histo
morphometry in the assessment of renal artery stenosis.
MATERIALS AND METHODS: Fifteen male New Zealand White rabbits weighing 4.0
kg underwent percutaneous catheterization. Renal artery stenosis was induce
d by bilateral overdilation-deendothelialization (balloon diameter = 2 mm).
The percentage of artery overdilation was 33%. After 4 weeks, the rabbits
were randomized into two groups: group A underwent right-sided therapeutic
percutaneous transluminal renal angioplasty (PTRA) (balloon diameter = 1.5
mm). After another 4 weeks, the renal arteries were evaluated by gadoterate
-, iodixanol-, and CO2-enhanced selective quantitative DSA. The rabbits wer
e then killed and renal arteries were perfusion-fixed for 60 minutes. Seria
l orcein-stained 4-um-thick slices were prepared for histomorphometry.
RESULTS: Based on morphometric data of single-stenosis versus post-PTRA res
tenosis lesions, no significant difference was observed between Gd- and iod
ixanol-enhanced quantitative DSA (r(2) > 0.95), although the iodine/Gd dens
ity ratio was equal to 3.5. Carbon dioxide less reliably allowed quantitati
ve DSA (r(2) < 0.75).
CONCLUSION: Gd-based contrast agents represent a highly reliable alternativ
e in experimental quantitative DSA evaluation of renal artery restenosis.